Surviving the aftermath no free carriers4/26/2023 ![]() In addition to answering questions about the ability of the surgery to prevent ovarian cancer, participants are having blood drawn and stored, for future studies of biomarkers to further understand cancer risk. Besides testing positive for a BRCA1 mutation, participants must have fallopian tubes. ![]() Some 190 clinical sites globally are expected to participate in the trial, which will follow the women over 20 years for signs of cancer. Women will choose either salpingectomy (removal of the fallopian tubes only) to preserve ovarian function, or traditional bilateral salpingo-oophorectomy. Investigators hope to enroll 2,262 women between the ages of 35 and 50 years old, in the proof-of-principle study. ![]() The study, called SOROCk, which stands for Salpingo-Oophorectomy to Reduce the risk of Ovarian Cancer (NCT04251052), is sponsored by NRG Oncology, a research organization that is part of the NCI Community Oncology Research Program (NCORP) national network, which brings cancer clinical trials and care delivery studies to people in their communities. Anyone Free of Ovarian Disease Can Enroll Growing scientific evidence now suggests many of these cancers arise from this site and not the ovaries, as once thought. “By removing the tubes, we should be able to prevent ovarian cancer,” she said. “The problem is that the fallopian tubes produce cells that push their way into the ovaries through the fimbria,” she said, referring to the distal fringes at the tubes’ edges. Walker said, while cutting off many of these cancers at their suspected source. However, the “tubes out first, ovaries later,” approach may offer high-risk women a less disruptive lifestyle choice, Dr. Not only are the hot flashes associated with early menopause likely to occur, there is also a possible increase in sexual dysfunction and health risks, such as osteoporosis. Surgically removing the ovaries induces a drop in estrogen levels similar to what occurs in menopause. Surgery to remove both ovaries and fallopian tubes is estimated to reduce risk of ovarian cancer by 98%. Community Oncology and Prevention TrialsĪt-risk women in the trial can self-select for the removal of their fallopian tubes only while delaying further surgery to take out the ovaries, for up to 5 years, at an age closer to natural menopause and the ovarian function wanes.Īlthough the standard, more invasive procedure “is great for stopping these cancers, it’s not a great option for a younger woman’s quality of life,” said Joan Walker, M.D., the study’s principal investigator and gynecologic oncologist at the Stephenson Cancer Center in Oklahoma City.US-Latin American-Caribbean HIV/HPV-Cancer Prevention Clinical Trials Network (ULACNet).Translational Liver Cancer (TLC) Consortium.Translational and Basic Science Research in Early Lesions (TBEL) Program.Small Cell Lung Cancer (SCLC) Consortium.Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO).PREVENT Cancer Preclinical Drug Development Program (PREVENT).Phase 0/I/II Cancer Prevention Clinical Trials Program (Consortia).Pancreatic Cancer Detection Consortium (PCDC).NCI Cervical Cancer ‘Last Mile’ Initiative.HIV/Cervical Cancer Prevention ‘CASCADE’ Clinical Trials Network.Consortium for Imaging and Biomarkers (CIB).Cancer Treatment Tolerability Consortium.Cancer Screening Research Network (CSRN).Cancer Prevention-Interception Targeted Agent Discovery Program (CAP-IT).Cancer Prevention Clinical Trials Network (CP-CTNet).Barrett's Esophagus Translational Research Network (BETRNet).Alliance of Glycobiologists for Cancer Research.Programs with Webpages within This Site.NCI Community Oncology Research Program (NCORP).Early Detection Research Network (EDRN).Cancer Prevention Fellowship Program (CPFP).
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